Inflammation modulates intercellular adhesion and mechanotransduction in human epidermis via ROCK2.

ABSTRACT: Aberrant mechanotransduction and compromised epithelial barrier function are associated with numerous human pathologies including inflammatory skin disorders. However, the cytoskeletal mechanisms regulating inflammatory responses in the epidermis are not well understood. Here we addressed this question by inducing a psoriatic phenotype in human keratinocytes and reconstructed human epidermis using a cytokine stimulation model. We show that the inflammation upregulates the Rho-myosin II pathway and destabilizes adherens junctions (AJs) promoting YAP nuclear entry. The integrity of cell-cell adhesion but not the myosin II contractility per se is the determinative factor for the YAP regulation in epidermal keratinocytes. The inflammation-induced disruption of AJs, increased paracellula

SUBMITTER: Shutova MS 

PROVIDER: S-EPMC9986521 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature