Identification of a DRB3*011:01-restricted CD4⁺ T cell response against bovine respiratory syncytial virus fusion protein.

ABSTRACT: Although Human Respiratory Syncytial Virus (HRSV) is a significant cause of severe respiratory disease with high morbidity and mortality in pediatric and elderly populations worldwide there is no licensed vaccine. Bovine Respiratory Syncytial Virus (BRSV) is a closely related orthopneumovirus with similar genome structure and high homology between structural and nonstructural proteins. Like HRSV in children, BRSV is highly prevalent in dairy and beef calves and known to be involved in the etiology of bovine respiratory disease, in addition to being considered an excellent model for HRSV. Commercial vaccines are currently available for BRSV, though improvements in efficacy are needed. The aims of this study were to identify CD4⁺ T cell epitopes present in the fusion glycoprotein

SUBMITTER: Kaplan BS 

PROVIDER: S-EPMC9986546 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature