Effects of Helicobacter pylori adhesin HopQ binding to CEACAM receptors in the human stomach

ABSTRACT: Helicobacter pylori has developed several strategies using its diverse virulence factors to trigger and, at the same time, limit the host’s inflammatory responses in order to establish a chronic infection in the human stomach. One of the virulence factors that has recently received more attention is a member of the Helicobacter outer membrane protein family, the adhesin HopQ, which binds to the human Carcinoembryonic Antigen-related Cell Adhesion Molecules (CEACAMs) on the host cell surface. The HopQ-CEACAM interaction facilitates the translocation of the cytotoxin-associated gene A (CagA), an important effector protein of H. pylori, into host cells via the Type IV secretion system (T4SS). Both the T4SS itself and CagA are important virulence factors that are linked to many aberrant host s

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PROVIDER: S-EPMC9986547 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature