Phenotypic and genomic comparison of dominant and nondominant sequence-type of Acinetobacter baumannii isolated in China.

ABSTRACT: A. baumannii is a common clinical pathogen that often causes pneumonia and bloodstream infections in ICU patients. Sequence types (ST) are used to investigate the distribution and spread of A. baumannii. Biological characteristics such as virulence and resistance may play a role in A. baumannii becoming a specific dominant ST(DST,ST191, ST195 and ST208) strain. To characterize the biological, genetic, and transcriptomic differences between the DST and non-dominant ST(NST,ST462 and ST547,etc.) strains in A. baumannii, we performed several biological experiments and genetic, and transcriptomic analyses. The DST group displayed more resistance ability to desiccation, oxidation, multiple antibiotics, and complement killing than the NST group. However, the latter had

SUBMITTER: Kong X 

PROVIDER: S-EPMC9986592 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature