Gut microbiota composition in patients with advanced malignancies experiencing immune-related adverse events.

ABSTRACT:

Introduction

The gut microbiota is implicated in the occurrence and severity of immune-related adverse events (irAEs), but the role it plays as well as its causal relationship with irAEs has yet to be established.

Methods

From May 2020 to August 2021, 93 fecal samples were prospectively collected from 37 patients with advanced thoracic cancers treated with anti-PD-1 therapy, and 61 samples were collected from 33 patients with various cancers developing different irAEs. 16S rDNA amplicon sequencing was performed. Antibiotic-treated mice underwent fecal microbiota transplantation (FMT) with samples from patients with and without colitic irAEs.

Results

Microbiota composition was significantly different in patients with and without irAEs (P=0.001) and with and without col

SUBMITTER: Liu X 

PROVIDER: S-EPMC9986626 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature