Low albumin levels are independently associated with neonatal acute kidney injury: a report from AWAKEN Study Group.

ABSTRACT:

Background

Data from adult and pediatric literature have shown an association between albumin levels and AKI. Whether hypoalbuminemia and neonatal AKI are associated has not been studied.

Methods

We evaluated the association of albumin with early (during the first postnatal week) and late (after the first postnatal week) AKI for 531 neonates from the Assessment of Worldwide AKI Epidemiology in Neonates (AWAKEN) database and for 3 gestational age (GA) subgroups: < 29, 29 to < 36, and ≥ 36 weeks GA.

Results

Low albumin levels were associated with increased odds of neonatal AKI; for every 0.1 g/dL decrease in albumin, the odds of late AKI increased by 12% on continuous analysis. After adjustment for potential confounders, neonates with albumin values in the lowest quarti

SUBMITTER: Nada A 

PROVIDER: S-EPMC9986677 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature