Host Genotype Links to Salivary and Gut Microbiota by Periodontal Status.

ABSTRACT: Limited evidence describing how host genetic variants affect the composition of the microbiota is currently available. The aim of this study was to assess the associations between a set of candidate host genetic variants and microbial composition in both saliva and gut in the TwinsUK registry. A total of 1,746 participants were included in this study and provided stool samples. A subset of 1,018 participants also provided self-reported periodontal data, and 396 of those participants provided a saliva sample. Host DNA was extracted from whole-blood samples and processed for Infinium Global screening array, focusing on 37 selected single-nucleotide polymorphisms (SNPs) previously associated with periodontitis. The gut and salivary microbiota of participants were profiled using 16S ribosomal

SUBMITTER: Kurushima Y 

PROVIDER: S-EPMC9986680 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature