Association between liver fibrosis and incident dementia in the UK Biobank study.

ABSTRACT:

Background and purpose

There is growing recognition that chronic liver conditions influence brain health. The impact of liver fibrosis on dementia risk was unclear. We evaluated the association between liver fibrosis and incident dementia in a cohort study.

Methods

We performed a cohort analysis using data from the UK Biobank study, which prospectively enrolled adults starting in 2007, and continues to follow them. People with a Fibrosis-4 (FIB-4) liver fibrosis score >2.67 were categorized as at high risk of advanced fibrosis. The primary outcome was incident dementia, ascertained using a validated approach. We excluded participants with prevalent dementia at baseline. We used Cox proportional hazards models to evaluate the association between liver fibrosis and dementia

SUBMITTER: Parikh NS 

PROVIDER: S-EPMC9986963 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature