The impact of repeated vaccination on relative influenza vaccine effectiveness among vaccinated adults in the United Kingdom.

ABSTRACT: Annual seasonal influenza vaccination is recommended for individuals at high risk of developing post-infection complications in many locations. However, reduced vaccine immunogenicity and effectiveness have been observed among repeat vaccinees in some influenza seasons. We investigated the impact of repeated influenza vaccination on relative vaccine effectiveness (VE) among individuals who were recommended for influenza vaccination in the United Kingdom with a retrospective cohort study using primary healthcare data from the Clinical Practice Research Datalink, a primary care database in the United Kingdom. Relative VE was estimated against general practitioner-diagnosed influenza-like illnesses (GP-ILI) and medically attended acute respiratory illnesses (MAARI) among participants who have

SUBMITTER: Lim WW 

PROVIDER: S-EPMC9987024 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature