Endometriosis leads to central nervous system-wide glial activation in a mouse model of endometriosis.

ABSTRACT:

Background

Chronic pelvic pain (CPP) is a common symptom of endometriosis. Women with endometriosis are also at a high risk of suffering from anxiety, depression, and other psychological disorders. Recent studies indicate that endometriosis can affect the central nervous system (CNS). Changes in the functional activity of neurons, functional magnetic resonance imaging signals, and gene expression have been reported in the brains of rat and mouse models of endometriosis. The majority of the studies thus far have focused on neuronal changes, whereas changes in the glial cells in different brain regions have not been studied.

Methods

Endometriosis was induced in female mice (45-day-old; n = 6-11/timepoint) by syngeneic transfer of donor uterine tissue into the peritoneal cavity

SUBMITTER: Bashir ST 

PROVIDER: S-EPMC9987089 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature