Comprehensive LncRNA and Potential Molecular Mechanism Analysis in Noninfectious Uveitis.

ABSTRACT:

Purpose

Long noncoding RNA (lncRNA) is noncoding RNA and have played a key role or be treated as a biomarker in a variety of diseases such as tumors. However, extensive lncRNA analysis for uveitis has not been explored completely. In this study, we analyzed the lncRNAs with altered expression in peripheral blood comprehensively for three major autoimmune diseases (ankylosing spondylitis [AS], Behҫet's disease [BD], and sarcoidosis) to search potential hub gene and molecular mechanism for noninfectious uveitis.

Methods

In total, we included 18 patients with AS and 12 patients with sarcoidosis versus 25 controls for GSE18781; we also included 15 patients with BD versus 14 controls for GSE17114 in this study. The lncRNA and messenger RNA (mRNA) expression levels were determined

SUBMITTER: Lu S 

PROVIDER: S-EPMC9987169 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature