Selective serotonin reuptake inhibitor (SSRI) use during pregnancy and risk of preterm birth: a systematic review and meta-analysis.

ABSTRACT:

Background

Depression is a prevalent condition in pregnancy affecting about 10% of women. Maternal depression has been associated with an increase in preterm births (PTB), low birthweight and fetal growth restriction, and postnatal complications. Available treatments for depressive disorders are psychotherapeutic interventions and antidepressant medications including selective serotonin inhibitors (SSRIs). SSRI use during pregnancy has been associated with several fetal and neonatal complications; so far, however, the risk of PTB in women using SSRIs during pregnancy is still a subject of debate.

Objective

To evaluate the risk of preterm birth (PTB) in cases of exposure to SSRIs during pregnancy.

Search strategy

Electronic databases (MEDLINE, Scopus, ClinicalTrials.go

SUBMITTER: Eke AC 

PROVIDER: S-EPMC9987176 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature