Vitamin A regulates tissue-specific organ remodeling in diet-induced obesity independent of mitochondrial function.

ABSTRACT:

Background

Perturbed mitochondrial energetics and vitamin A (VitA) metabolism are associated with the pathogenesis of diet-induced obesity (DIO) and type 2 diabetes (T2D).

Methods

To test the hypothesis that VitA regulates tissue-specific mitochondrial energetics and adverse organ remodeling in DIO, we utilized a murine model of impaired VitA availability and high fat diet (HFD) feeding. Mitochondrial respiratory capacity and organ remodeling were assessed in liver, skeletal muscle, and kidney tissue, which are organs affected by T2D-associated complications and are critical for the pathogenesis of T2D.

Results

In liver, VitA had no impact on maximal ADP-stimulated mitochondrial respiratory capacity (V_ADP) following HFD feeding with palmitoyl-carnitine and

SUBMITTER: Shymotiuk I 

PROVIDER: S-EPMC9987331 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature