T-cell responses in asthma exacerbations.

ABSTRACT:

Objective

Asthma is a chronic lung disease comprising multiple endotypes and characterized by periodic exacerbations. A diverse array of T cells has been found to contribute to all endotypes of asthma in pathogenic and regulatory roles. Here, we review the contributions of CD4+, CD8+, and unconventional T cells in allergic and nonallergic asthma.

Data sources

Review of published literature pertaining to conventional and unconventional T-cell types in asthma.

Study selections

Recent peer-reviewed articles pertaining to T cells in asthma, with additional peer-reviewed studies for context.

Results

Much research in asthma has focused on the roles of CD4+ T_H cells. Roles for T_H2 cells in promoting allergic asthma pathogenesis have been well-des

SUBMITTER: Bryant N 

PROVIDER: S-EPMC9987567 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature