COVID-19: Attacks Immune Cells and Interferences With Antigen Presentation Through MHC-Like Decoy System.

ABSTRACT: The high mortality of coronavirus disease 2019 is related to poor antigen presentation and lymphopenia. Cytomegalovirus and the herpes family encode a series of major histocompatibility complex (MHC)-like molecules required for targeted immune responses to achieve immune escape. In this present study, domain search results showed that many proteins of the severe acute respiratory syndrome coronavirus 2 virus had MHC-like domains, which were similar to decoys for the human immune system. MHC-like structures could bind to MHC receptors of immune cells (such as CD4 + T-cell, CD8 + T-cell, and natural killer-cell), interfering with antigen presentation. Then the oxygen free radicals generated by E protein destroyed immune cells after MHC-like of S protein could bind to them. Mutations in the M

SUBMITTER: Liu W 

PROVIDER: S-EPMC9987643 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature