Reproductive outcomes in couples with sporadic miscarriage after embryonic chromosomal microarray analysis.

ABSTRACT:

Objectives

Chromosomal microarray analysis (CMA) has been widely applied to genetic diagnosis in miscarriages in clinical practice. However, the prognostic value of CMA testing of products of conception (POCs) after the first clinical miscarriage remains unknown. The aim of this study was to evaluate the reproductive outcomes after embryonic genetic testing by CMA in SM couples.

Methods

In this retrospective study, a total of 1142 SM couples referred for embryonic genetic testing by CMA, and 1022 couples were successfully followed up after CMA.

Results

Among 1130 cases without significant maternal cell contamination, pathogenic chromosomal abnormalities were detected in 680 cases (60.2%). The subsequent live birth rate did not differ significantly between couples with

SUBMITTER: Xia Z 

PROVIDER: S-EPMC9987763 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature