Dendritic Self-assembled Structures from Therapeutic Charged Pentapeptides.

ABSTRACT: CRE^NKA [Cys-Arg-(NMe)Glu-Lys-Ala, where (NMe)Glu refers to N-methyl-Glu], an anti-cancer pentapeptide that induces prostate tumor necrosis and significant reduction in tumor growth, was engineered to increase the resistance to endogenous proteases of its parent peptide, CREKA (Cys-Arg-Glu-Lys-Ala). Considering their high tendency to aggregate, the self-assembly of CRE^NKA and CREKA into well-defined and ordered structures has been examined as a function of peptide concentration and pH. Spectroscopic studies and atomistic molecular dynamics simulations reveal significant differences between the secondary structures of CREKA and CRE^NKA. Thus, the restrictions imposed by the (NMe)Glu residue reduce the conformational variability of C

SUBMITTER: El Hauadi K 

PROVIDER: S-EPMC9988208 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature