Anti-CD122 antibody restores specific CD8⁺ T cell response in nonalcoholic steatohepatitis and prevents hepatocellular carcinoma growth.

ABSTRACT: Nonalcoholic steatohepatitis (NASH) can lead to hepatocellular carcinoma (HCC). Although immunotherapy is used as first-line treatment for advanced HCC, the impact of NASH on anticancer immunity is only partially characterized. We assessed the tumor-specific T cell immune response in the context of NASH. In a mouse model of NASH, we observed an expansion of the CD44⁺CXCR6⁺PD-1⁺CD8⁺ T cells in the liver. After intra-hepatic injection of RIL-175-LV-OVA-GFP HCC cells, NASH mice had a higher percentage of peripheral OVA-specific CD8⁺ T cells than control mice, but these cells did not prevent HCC growth. In the tumor, the expression of PD-1 on OVA-specific CD44⁺CXCR6⁺CD8⁺ cells was higher in NASH mice sugges

SUBMITTER: Lacotte S 

PROVIDER: S-EPMC9988345 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature