Neuronal activity drives pathway-specific depolarization of peripheral astrocyte processes.

ABSTRACT: Astrocytes are glial cells that interact with neuronal synapses via their distal processes, where they remove glutamate and potassium (K⁺) from the extracellular space following neuronal activity. Astrocyte clearance of both glutamate and K⁺ is voltage dependent, but astrocyte membrane potential (V_m) is thought to be largely invariant. As a result, these voltage dependencies have not been considered relevant to astrocyte function. Using genetically encoded voltage indicators to enable the measurement of V_m at peripheral astrocyte processes (PAPs) in mice, we report large, rapid, focal and pathway-specific depolarizations in PAPs during neuronal activity. These activity-dependent astrocyte depolarizations are driven by action potential-mediated pr

SUBMITTER: Armbruster M 

PROVIDER: S-EPMC9988390 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature