Conformation and Pairing Properties of an O⁶-Methyl-2'-deoxyguanosine-Directed Benzimidazole Nucleoside Analog in Duplex DNA.

ABSTRACT: O⁶-Methyl-2'-deoxyguanosine (O⁶-MeG) is one of the most common DNA lesions and arises as a consequence of both xenobiotic carcinogens and endogenous methylation by S-adenosylmethionine. O⁶-MeG frequently causes G-to-A mutations during DNA replication due to the misincorporation of dTTP and continued DNA synthesis. Efforts to detect DNA adducts such as O⁶-MeG, and to understand their impacts on DNA structure and function, have motivated the creation of nucleoside analogs with altered base moieties to afford a more favorable interaction with the adduct as compared to the unmodified nucleotide. Such analogs directed at O⁶-MeG include benzimidazolinone and benzimidazole nucleotides, as well as thei

SUBMITTER: Kellum AH 

PROVIDER: S-EPMC9988402 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature