No insulin degludec dose adjustment required after aerobic exercise for people with type 1 diabetes: the ADREM study.

ABSTRACT:

Aims/hypothesis

It is generally recommended to reduce basal insulin doses after exercise to reduce the risk of post-exercise nocturnal hypoglycaemia. Based on its long t_½, it is unknown whether such adjustments are required or beneficial for insulin degludec.

Methods

The ADREM study (Adjustment of insulin Degludec to Reduce post-Exercise (nocturnal) hypoglycaeMia in people with diabetes) was a randomised controlled, crossover study in which we compared 40% dose reduction (D40), or postponement and 20% dose reduction (D20-P), with no dose adjustment (CON) in adults with type 1 diabetes at elevated risk of hypoglycaemia, who performed a 45 min aerobic exercise test in the afternoon. All participants wore blinded continuous glucose monitors for 6 days, measuring the

SUBMITTER: Drenthen LCA 

PROVIDER: S-EPMC9988601 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature