Validation of disease-specific biomarkers for the early detection of bronchopulmonary dysplasia.

ABSTRACT:

Objective

To demonstrate and validate the improvement of current risk stratification for bronchopulmonary dysplasia (BPD) early after birth by plasma protein markers (sialic acid-binding Ig-like lectin 14 (SIGLEC-14), basal cell adhesion molecule (BCAM), angiopoietin-like 3 protein (ANGPTL-3)) in extremely premature infants.

Methods and results

Proteome screening in first-week-of-life plasma samples of n = 52 preterm infants <32 weeks gestational age (GA) on two proteomic platforms (SomaLogic^®, Olink-Proteomics^®) confirmed three biomarkers with significant predictive power: BCAM, SIGLEC-14, and ANGPTL-3. We demonstrate high sensitivity (0.92) and specificity (0.86) under consideration of GA, show the proteins' critical contribution to the predictive pow

SUBMITTER: Kindt ASD 

PROVIDER: S-EPMC9988689 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature