Interventions for Infection and Inflammation-Induced Preterm Birth: a Preclinical Systematic Review.

ABSTRACT: Spontaneous preterm births (< 37 weeks gestation) are frequently associated with infection. Current treatment options are limited but new therapeutic interventions are being developed in animal models. In this PROSPERO-registered preclinical systematic review, we aimed to summarise promising interventions for infection/inflammation-induced preterm birth. Following PRISMA guidance, we searched PubMed, EMBASE, and Web of Science using the themes: "animal models", "preterm birth", "inflammation", and "therapeutics". We included original quantitative, peer-reviewed, and controlled studies applying prenatal interventions to prevent infection/inflammation-induced preterm birth in animal models. We employed two risk of bias tools. Of 4020 identified studies, 23 studies (24 interventions) met our

SUBMITTER: Miller FA 

PROVIDER: S-EPMC9988807 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature