Functional dissection of two amino acid substitutions unique to the human FOXP2 protein.
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ABSTRACT:
SUBMITTER: Bornschein U
PROVIDER: S-EPMC9988825 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Publications
Functional dissection of two amino acid substitutions unique to the human FOXP2 protein.
Bornschein Ulrich U Zeberg Hugo H Enard Wolfgang W Hevers Wulf W Pääbo Svante S
Scientific reports 20230306 1
The transcription factor forkhead box P2 (FOXP2) is involved in the development of language and speech in humans. Two amino acid substitutions (T303N, N325S) occurred in the human FOXP2 after the divergence from the chimpanzee lineage. It has previously been shown that when they are introduced into the FOXP2 protein of mice they alter striatal synaptic plasticity by increasing long-term depression in medium spiny neurons. Here we introduce each of these amino acid substitutions individually into ...[more]
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