A genetic locus complements resistance to Bordetella pertussis-induced histamine sensitization.

ABSTRACT: Histamine plays pivotal role in normal physiology and dysregulated production of histamine or signaling through histamine receptors (HRH) can promote pathology. Previously, we showed that Bordetella pertussis or pertussis toxin can induce histamine sensitization in laboratory inbred mice and is genetically controlled by Hrh1/HRH1. HRH1 allotypes differ at three amino acid residues with P₂₆₃-V₃₁₃-L₃₃₁ and L₂₆₃-M₃₁₃-S₃₃₁, imparting sensitization and resistance respectively. Unexpectedly, we found several wild-derived inbred strains that carry the resistant HRH1 allotype (L₂₆₃-M₃₁₃-S₃₃₁) but exhibit histamine sensitization. This suggests the existence of a locus modifying pertussis-dependent his

SUBMITTER: Raza A 

PROVIDER: S-EPMC9988836 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature