Optical coherence tomography in healthy human subjects in the setting of prolonged dark adaptation.

ABSTRACT: Human studies have established that short periods of dark adaptation can induce outer retinal thinning and various band intensity changes that can be detected with Optical Coherence Tomography (OCT). Similar findings were observed in mice, including a positive correlation between the degree of outer retinal changes and dark adaptation duration. We decided to assess potential retinal structural changes following prolonged dark adaptation in humans. 40 healthy subjects without any ocular diseases participated in this study. For each subject, one eye was covered for dark adaptation for four hours, and the other eye was left uncovered as a control. Before and after the dark adaptation period, both eyes were assessed with OCT. Using the Heidelberg Spectralis system, basic statistical functions,

SUBMITTER: Su EH 

PROVIDER: S-EPMC9988879 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature