Omniparticle Contrast Agent for Multimodal Imaging: Synthesis and Characterization in an Animal Model.

ABSTRACT:

Purpose

Individual imaging modalities have certain advantages, but each suffers from drawbacks that other modalities may overcome. The goal of this study was to create a novel contrast agent suitable for various imaging modalities that after a single administration can bridge and strengthen the collaboration between the research fields as well as enrich the information obtained from any one modality.

Procedures

The contrast agent platform is based on dextran-coated iron oxide nanoparticles (for MRI and MPI) and synthesized using a modified co-precipitation method, followed by a series of conjugation steps with a fluorophore (for fluorescence and photoacoustic imaging), thyroxine (for CT imaging), and chelators for radioisotope labeling (for PET imaging). The fully conjugated

SUBMITTER: Robertson N 

PROVIDER: S-EPMC9989039 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature