The effect of rhamnolipids on fungal membrane models as described by their interactions with phospholipids and sterols: An in silico study.

ABSTRACT: Introduction: Rhamnolipids (RLs) are secondary metabolites naturally produced by bacteria of the genera Pseudomonas and Burkholderia with biosurfactant properties. A specific interest raised from their potential as biocontrol agents for crop culture protection in regard to direct antifungal and elicitor activities. As for other amphiphilic compounds, a direct interaction with membrane lipids has been suggested as the key feature for the perception and subsequent activity of RLs. Methods: Molecular Dynamics (MD) simulations are used in this work to provide an atomistic description of their interactions with different membranous lipids and focusing on their antifungal properties. Results and discussion: Our results suggest the insertion of RLs into the modelled bi

SUBMITTER: Rodriguez-Moraga N 

PROVIDER: S-EPMC9989204 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature