Human monocyte-derived suppressive cells (HuMoSC) for cell therapy in giant cell arteritis.

ABSTRACT:

Introduction

The pathogenesis of Giant Cell Arteritis (GCA) relies on vascular inflammation and vascular remodeling, the latter being poorly controlled by current treatments.

Methods

This study aimed to evaluate the effect of a novel cell therapy, Human Monocyte-derived Suppressor Cells (HuMoSC), on inflammation and vascular remodeling to improve GCA treatment. Fragments of temporal arteries (TAs) from GCA patients were cultured alone or in the presence of HuMoSCs or their supernatant. After five days, mRNA expression was measured in the TAs and proteins were measured in culture supernatant. The proliferation and migration capacity of vascular smooth muscle cells (VSMCs) were also analyzed with or without HuMoSC supernatant.

Results

Transcripts of genes implicated in

SUBMITTER: Samson M 

PROVIDER: S-EPMC9989212 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature