Genital Immune Cell Activation and Tenofovir Gel Efficacy: A Case-Control Study.

ABSTRACT: Genital inflammation (GI) undermines topical human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP) efficacy through unknown mechanisms. Here, associations between activated endocervical CD4 + T-cell numbers and higher deoxyadenosine triphosphate (dATP) concentrations suggest that competition for intracellular metabolites within HIV target cells may reduce the efficacy of antiretroviral-based PrEP in women with GI.

SUBMITTER: Liebenberg LJP 

PROVIDER: S-EPMC9989354 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature