Treatment strategies based on different oligoprogressive patterns after immunotherapy failure in metastatic NSCLC.

ABSTRACT:

Background

Oligoprogressive disease is recognized as the overall umbrella term; however, a small number of progressions on imaging can represent different clinical scenarios. This study aims to explore the optimal treatment strategy after immunotherapy (IO) resistance in advanced non-small-cell lung cancer (NSCLC), especially in personalized therapies for patients with different oligoprogressive patterns.

Methods

Based on European Society for Radiotherapy and Oncology/European Organization for Research and Treatment of Cancer consensus, metastatic NSCLC patients with cancer progression after IO resistance were divided into four patterns, repeat oligoprogression (REO, oligoprogression with a history of oligometastatic disease), induced oligoprogression (INO, oligoprogression

SUBMITTER: Xuzhang W 

PROVIDER: S-EPMC9989452 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature