Galectin 3 enhances platelet aggregation and thrombosis via Dectin-1 activation: a translational study.

ABSTRACT:

Aims

Galectin-3, a β-galactoside-binding lectin, is abnormally increased in cardiovascular disease. Plasma Galectin-3 receives a Class II recommendation for heart failure management and has been extensively studied for multiple cellular functions. The direct effects of Galectin-3 on platelet activation remain unclear. This study explores the direct effects of Galectin-3 on platelet activation and thrombosis.

Methods and results

A strong positive correlation between plasma Galectin-3 concentration and platelet aggregation or whole blood thrombus formation was observed in patients with coronary artery disease (CAD). Multiple platelet function studies demonstrated that Galectin-3 directly potentiated platelet activation and in vivo thrombosis. Mechanistic studies using the Dect

SUBMITTER: Chen Y 

PROVIDER: S-EPMC9989600 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature