Liver fibrosis in children: a comprehensive review of mechanisms, diagnosis, and therapy.

ABSTRACT: Chronic liver disease incidence is increasing among children worldwide due to a multitude of epidemiological changes. Most of these chronic insults to the pediatric liver progress to fibrosis and cirrhosis to different degrees. Liver and immune physiology differs significantly in children from adults. Because most of pediatric liver diseases have no definitive therapy, a better understanding of population and disease-specific fibrogenesis is mandatory. Furthermore, fibrosis development has prognostic significance and often guide treatment. Evaluation of liver fibrosis continues to rely on the gold-standard liver biopsy. However, many high-quality studies put forward the high diagnostic accuracy of numerous diagnostic modalities in this setting. Herein, we summarize and discuss the recent l

SUBMITTER: Ozdogan E 

PROVIDER: S-EPMC9989719 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature