Characteristics of community-acquired carbapenem-resistant Enterobacterales.

ABSTRACT:

Background

Community-acquired carbapenem-resistant Enterobacterales (CA-CRE) are an important threat.

Methods

In CRACKLE-2, we defined patients with CA-CRE as admitted from home, without pre-existing conditions, and a positive culture within 48 h of admission. Healthcare-associated CRE (HA-CRE) were those with the lowest likelihood of community acquisition, not admitted from home and cultured >48 h after admission. Specific genetic markers in carbapenemase-producing Klebsiella pneumoniae were evaluated through random forest modelling.

Results

CA-CRE and HA-CRE were detected in 83 (10%) and 208 (26%) of 807 patients. No significant differences were observed in bacterial species or strain type distribution. K. pneumoniae (204/291, 70%) was the most common CRE species

SUBMITTER: Shrestha R 

PROVIDER: S-EPMC9989732 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature