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Efficacy of immune checkpoint inhibitors in advanced non-small cell lung cancer harboring BRAF mutations.

ABSTRACT:

Background

Despite immune checkpoint inhibitors (ICI) being widely used to treat patients with advanced non-small cell lung cancer (NSCLC), few studies examine the role of ICI in patients with proto-oncogene B-Raf, serine/threonine kinase (BRAF) mutations.

Methods

A retrospective study was conducted for patients with BRAF-mutant NSCLC who received treatment at Shanghai Pulmonary Hospital between 2014 and 2022. Primary end point was progression-free survival (PFS). Secondary end point was best response (RECIST, version 1.1).

Results

The study involved a total of 34 patients with 54 treatments recorded. The median PFS for the whole cohort was 5.8 months and the overall objective response rate (ORR) was 24%. Patients who were treated with ICI combined with chemotherapy reported a median PFS of 12.6 months and an ORR of 44%. Those who were treated with non-ICI therapy came with a median PFS of 5.3 months and an ORR of 14%. Specifically, patients had better clinical benefits with first-line ICI-combined therapy. The PFS was 18.5 months whereas that of non-ICI group was 4.1 months. The ORR was 56% in ICI-combined group and 10% in non-ICI cohort.

Conclusions

The findings observed an evidential and significant susceptibility to ICIs combined therapy in patients with BRAF-mutant NSCLC, especially in first-line treatment.

SUBMITTER: Wang H

PROVIDER: S-EPMC9989805 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

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Publications

Efficacy of immune checkpoint inhibitors in advanced non-small cell lung cancer harboring <i>BRAF</i> mutations.

Wang Haowei H Cheng Lei L Zhao Chao C Zhou Fei F Jiang Tao T Guo Haoyue H Shi Jinpeng J Chen Peixin P Tang Zhuoran Z Mao Shiqi S Jia Keyi K Ye Lingyun L Cai Chenlei C Li Xuefei X Chen Xiaoxia X Zhou Caicun C

Translational lung cancer research 20230225 2

<h4>Background</h4>Despite immune checkpoint inhibitors (ICI) being widely used to treat patients with advanced non-small cell lung cancer (NSCLC), few studies examine the role of ICI in patients with proto-oncogene B-Raf, serine/threonine kinase (<i>BRAF</i>) mutations.<h4>Methods</h4>A retrospective study was conducted for patients with <i>BRAF</i>-mutant NSCLC who received treatment at Shanghai Pulmonary Hospital between 2014 and 2022. Primary end point was progression-free survival (PFS). Se ...[more]

PMID: 36895926

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