Treat-to-Target or High-Intensity Statin in Patients With Coronary Artery Disease: A Randomized Clinical Trial.

ABSTRACT:

Importance

In patients with coronary artery disease, some guidelines recommend initial statin treatment with high-intensity statins to achieve at least a 50% reduction in low-density lipoprotein cholesterol (LDL-C). An alternative approach is to begin with moderate-intensity statins and titrate to a specific LDL-C goal. These alternatives have not been compared head-to-head in a clinical trial involving patients with known coronary artery disease.

Objective

To assess whether a treat-to-target strategy is noninferior to a strategy of high-intensity statins for long-term clinical outcomes in patients with coronary artery disease.

Design, setting, and participants

A randomized, multicenter, noninferiority trial in patients with a coronary disease diagnosis treated at 12

SUBMITTER: Hong SJ 

PROVIDER: S-EPMC9989958 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature