Alzheimer Disease Blood Biomarkers in Patients With Out-of-Hospital Cardiac Arrest.

ABSTRACT:

Importance

Blood phosphorylated tau (p-tau) and amyloid-β peptides (Aβ) are promising peripheral biomarkers of Alzheimer disease (AD) pathology. However, their potential alterations due to alternative mechanisms, such as hypoxia in patients resuscitated from cardiac arrest, are not known.

Objective

To evaluate whether the levels and trajectories of blood p-tau, Aβ42, and Aβ40 following cardiac arrest, in comparison with neural injury markers neurofilament light (NfL) and total tau (t-tau), can be used for neurological prognostication following cardiac arrest.

Design, setting, and participants

This prospective clinical biobank study used data from the randomized Target Temperature Management After Out-of-Hospital Cardiac Arrest (TTM) trial. Unconscious patients with ca

SUBMITTER: Ashton NJ 

PROVIDER: S-EPMC9989959 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature