Contemporary trends in PGD incidence, outcomes, and therapies.

ABSTRACT:

Background

We sought to describe trends in extracorporeal membrane oxygenation (ECMO) use, and define the impact on PGD incidence and early mortality in lung transplantation.

Methods

Patients were enrolled from August 2011 to June 2018 at 10 transplant centers in the multi-center Lung Transplant Outcomes Group prospective cohort study. PGD was defined as Grade 3 at 48 or 72 hours, based on the 2016 PGD ISHLT guidelines. Logistic regression and survival models were used to contrast between group effects for event (i.e., PGD and Death) and time-to-event (i.e., death, extubation, discharge) outcomes respectively. Both modeling frameworks accommodate the inclusion of potential confounders.

Results

A total of 1,528 subjects were enrolled with a 25.7% incidence of PGD. Annu

SUBMITTER: Cantu E 

PROVIDER: S-EPMC9990084 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature