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The effectiveness of treadmill and swimming exercise in an animal model of osteoarthritis.

ABSTRACT: Introduction: Osteoarthritis (OA) is considered an inflammatory and degenerative joint disease, characterized by loss of hyaline joint cartilage and adjacent bone remodeling with the formation of osteophytes, accompanied by various degrees of functional limitation and reduction in the quality of life of individuals. The objective of this work was to investigate the effects of treatment with physical exercise on the treadmill and swimming in an animal model of osteoarthritis. Methods: Forty-eight male Wistar rats were divided (n=12 per group): Sham (S); Osteoarthritis (OA); Osteoarthritis + Treadmill (OA + T); Osteoarthritis + Swimming (OA + S). The mechanical model of OA was induced by median meniscectomy. Thirty days later, the animals started the physical exercise protocols. Both protocols were performed at moderate intensity. Forty-eight hours after the end of the exercise protocols, all animals were anesthetized and euthanized for histological, molecular, and biochemical parameters analysis. Results: Physical exercise performed on a treadmill was more effective in attenuating the action of pro-inflammatory cytokines (IFN-γ, TNF-α, IL1-β, and IL6) and positively regulating anti-inflammatories such as IL4, IL10, and TGF-β in relation to other groups. Discussion: In addition to maintaining a more balanced oxi-reductive environment within the joint, treadmill exercise provided a more satisfactory morphological outcome regarding the number of chondrocytes in the histological evaluation. As an outcome, better results were found in groups submitted to exercise, mostly treadmill exercise.

SUBMITTER: da Silva LA

PROVIDER: S-EPMC9990173 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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The effectiveness of treadmill and swimming exercise in an animal model of osteoarthritis.

da Silva Leandro Almeida LA Thirupathi Anand A Colares Mateus Cardoso MC Haupenthal Daniela Pacheco Dos Santos DPDS Venturini Ligia Milanez LM Corrêa Maria Eduarda Anastácio Borges MEAB Silveira Gustavo de Bem GB Haupenthal Alessandro A do Bomfim Fernando Russo Costa FRC de Andrade Thiago Antônio Moretti TAM Gu Yaodong Y Silveira Paulo Cesar Lock PCL

Frontiers in physiology 20230221

<b>Introduction:</b> Osteoarthritis (OA) is considered an inflammatory and degenerative joint disease, characterized by loss of hyaline joint cartilage and adjacent bone remodeling with the formation of osteophytes, accompanied by various degrees of functional limitation and reduction in the quality of life of individuals. The objective of this work was to investigate the effects of treatment with physical exercise on the treadmill and swimming in an animal model of osteoarthritis. <b>Methods:</ ...[more]

PMID: 36895628

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Project description:BackgroundPostoperative rehabilitation following total knee arthroplasty (TKA) varies worldwide. In Finland, patients receive guidance on safe walking and home exercises from a physiotherapist both before and after TKA. These are performed independently after surgery. However, a sedentary lifestyle is rather common among patients who have undergone TKA, with pain often limiting postoperative walking, training, and activities of daily living.ObjectiveThis randomized controlled trial aimed to investigate the effectiveness of anti-gravity exercise, precisely the AlterG anti-gravity treadmill, on postoperative rehabilitation following TKA and to obtain new knowledge on this form of rehabilitation to better use it in the future.MethodsThis randomized controlled trial study divided the patients into two groups: the intervention group and the control group. The follow-up period was 12 months. Research data were collected through questionnaires and functional tests. All patients in both groups responded to the questionnaires and participated in functional tests before surgery as well as 4 and 12 months after surgery. Patients in the intervention group exercised on the AlterG treadmill 10 times after the surgery. All the patients in this study performed the exercises as instructed when they were in the hospital. The primary outcomes were perceived pain, walking ability, and quality of life.ResultsThe data collection process began in 2018 and concluded in 2022, intending to obtain valuable information regarding the effect of AlterG training after TKA and determine whether it, along with traditional exercises, could be an effective form of rehabilitation that can be performed at home. We hypothesized that AlterG training would lead to faster rehabilitation, better walking quality, improved quality of life, improved physical activity, and improved overall functioning. The results of this study will be analyzed in 2025 and 2026.ConclusionsThis study provides information on how AlterG training can be used in rehabilitation after TKA, further enhancing the rehabilitation program for patients undergoing TKA in general.Trial registrationClinicalTrials.gov NCT03904030; https://clinicaltrials.gov/study/NCT03904030.International registered report identifier (irrid)DERR1-10.2196/59935.

Dataset Information

The effectiveness of treadmill and swimming exercise in an animal model of osteoarthritis.

Publications

The effectiveness of treadmill and swimming exercise in an animal model of osteoarthritis.

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