Somatic mutation landscape in a cohort of meningiomas that have undergone grade progression.

ABSTRACT:

Background

A subset of meningiomas progress in histopathological grade but drivers of progression are poorly understood. We aimed to identify somatic mutations and copy number alterations (CNAs) associated with grade progression in a unique matched tumour dataset.

Methods

Utilising a prospective database, we identified 10 patients with meningiomas that had undergone grade progression and for whom matched pre- and post-progression tissue (n = 50 samples) was available for targeted next-generation sequencing.

Results

Mutations in NF2 were identified in 4/10 patients, of these 94% were non-skull base tumours. In one patient, three different NF2 mutations were identified in four tumours. NF2 mutated tumours showed large-scale CNAs, with highly recurrent losses in 1p, 10,

SUBMITTER: Cain SA 

PROVIDER: S-EPMC9990218 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature