Prevalence of abnormal spirometry in individuals with a smoking history and no known obstructive lung disease.

ABSTRACT:

Introduction

Recent evidence suggests a high prevalence of undiagnosed chronic obstructive pulmonary disease (COPD). These individuals are at risk of exacerbations and delayed treatment. We analyzed an at-risk population for the prevalence of abnormal spirometry to provide clarity into who should undergo early spirometry.

Methods

We analyzed data from the COPDGene study. Participants with ≥10 pack-years of smoking were included. Individuals with self-reported or physician-diagnosed COPD, asthma, chronic bronchitis, emphysema and/or were on inhalers were excluded. Parsimonious multivariable logistic regression models identified factors associated with abnormal spirometry, defined as either airflow obstruction (AFO) or preserved ratio impaired spirometry. Variables were select

SUBMITTER: Tran TV 

PROVIDER: S-EPMC9990311 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature