EPO regulates neuronal differentiation of adult human neural-crest derived stem cells in a sex-specific manner.

ABSTRACT:

Background

Sexual differences in the biology of human stem cells are increasingly recognized to influence their proliferation, differentiation and maturation. Especially in neurodegenerative diseases such as Alzheimers disease (AD), Parkinson's disease (PD) or ischemic stroke, sex is a key player for disease progression and recovery of damaged tissue. Recently, the glycoprotein hormone erythropoietin (EPO) has been implicated as a regulator of neuronal differentiation and maturation in female rats.

Methods

In this study, we used adult human neural crest-derived stem cells (NCSCs) as a model system for exploring potential sex specific effects of EPO on human neuronal differentiation. We started with expression validation of the specific EPO receptor (EPOR) by performing PCR a

SUBMITTER: Niemann T 

PROVIDER: S-EPMC9990360 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature