Effect of probiotic supplementation on gastrointestinal motility, inflammation, motor, non-motor symptoms and mental health in Parkinson's disease: a meta-analysis of randomized controlled trials.

ABSTRACT:

Background

Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide. Gut dysbiosis is hypothesized to cause PD; therefore, whether probiotics can be used as adjuvants in the treatment of PD is being actively investigated.

Aims

We performed a systematic review and meta-analysis to evaluate the effectiveness of probiotic therapy in PD patients.

Methods

PUBMED/MEDLINE, EMBASE, Cochrane, Scopus, PsycINFO and Web of Science databases were searched till February 20, 2023. The meta-analysis used a random effects model and the effect size was calculated as mean difference or standardized mean difference. We assessed the quality of the evidence using the Grade of Recommendations Assessment, Development and Evaluation (GRADE) approach.

Results</

SUBMITTER: Park JM 

PROVIDER: S-EPMC9990363 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature