Ability of epidemiological studies to monitor HPV post-vaccination dynamics: a simulation study.

ABSTRACT: Genital human papillomavirus (HPV) infections are caused by a broad diversity of genotypes. As available vaccines target a subgroup of these genotypes, monitoring transmission dynamics of nonvaccine genotypes is essential. After reviewing the epidemiological literature on study designs aiming to monitor those dynamics, we evaluated their abilities to detect HPV-prevalence changes following vaccine introduction. We developed an agent-based model to simulate HPV transmission in a heterosexual population under various scenarios of vaccine coverage and genotypic interaction, and reproduced two study designs: post-vs.-prevaccine and vaccinated-vs.-unvaccinated comparisons. We calculated the total sample size required to detect statistically significant prevalence differences at th

SUBMITTER: Bonneault M 

PROVIDER: S-EPMC9990403 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature