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METTL3 inhibition reduces N⁶ -methyladenosine levels and prevents allogeneic CD4⁺ T-cell responses.

ABSTRACT: Alloreactive CD4⁺ T cells play a central role in allograft rejection. However, the post-transcriptional regulation of the effector program in alloreactive CD4⁺ T cells remains unclear. N⁶ -methyladenosine (m⁶ A) RNA modification is involved in various physiological and pathological processes. Herein, we investigated whether m⁶ A methylation plays a role in the allogeneic T-cell effector program. m⁶ A levels of CD4⁺ T cells from spleens, draining lymph nodes and skin allografts were determined in a skin transplantation model. The effects of a METTL3 inhibitor (STM2457) on CD4⁺ T-cell characteristics including proliferation, cell cycle, cell apoptosis and effector differentiation were determined after sti

SUBMITTER: Li S

PROVIDER: S-EPMC9990421 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature

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METTL3 inhibition reduces N⁶ -methyladenosine levels and prevents allogeneic CD4⁺ T-cell responses.

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METTL3 inhibition reduces N6 -methyladenosine levels and prevents allogeneic CD4+ T-cell responses.

OmicsDI is part of the ELIXIR infrastructure

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METTL3 inhibition reduces N⁶ -methyladenosine levels and prevents allogeneic CD4⁺ T-cell responses.