Association of Brain Volume and Retinal Thickness in the Early Stages of Alzheimer's Disease.

ABSTRACT:

Background

The eye has been considered a 'window to the brain,' and several neurological diseases including neurodegenerative conditions like Alzheimer's disease (AD) also show changes in the retina.

Objective

To investigate retinal nerve fiber layer (RNFL) thickness and its association with brain volume via magnetic resonance imaging (MRI) in older adults with subjective or objective cognitive decline.

Methods

75 participants underwent ophthalmological and neurological evaluation including optical coherence tomography and MRI (28 cognitively normal subjects, 26 with subjective cognitive decline, 17 patients diagnosed with mild cognitive impairment, and 4 with AD). Differences in demographics, thickness of RNFL, and brain volume were assessed using ANCOVA, while parti

SUBMITTER: Mathew S 

PROVIDER: S-EPMC9990456 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature