Gene expression associations with body mass index in the Multi-Ethnic Study of Atherosclerosis.

ABSTRACT:

Background/objectives

Obesity, defined as excessive fat accumulation that represents a health risk, is increasing in adults and children, reaching global epidemic proportions. Body mass index (BMI) correlates with body fat and future health risk, yet differs in prediction by fat distribution, across populations and by age. Nonetheless, few genetic studies of BMI have been conducted in ancestrally diverse populations. Gene expression association with BMI was assessed in the Multi-Ethnic Study of Atherosclerosis (MESA) in four self-identified race and ethnicity (SIRE) groups to identify genes associated with obesity.

Subjects/methods

RNA-sequencing was performed on 1096 MESA participants (37.8% white, 24.3% Hispanic, 28.4% African American, and 9.5% Chinese American) and linea

SUBMITTER: Vargas LB 

PROVIDER: S-EPMC9990473 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature