Splanchnic Nerve Block Mediated Changes in Stressed Blood Volume in Heart Failure.

ABSTRACT:

Objectives

The authors estimated changes of stressed blood volume (SBV) induced by splanchnic nerve block (SNB) in patients with either decompensated or ambulatory heart failure with reduced ejection fraction (HFrEF).

Background

The splanchnic vascular capacity is a major determinant of the SBV, which in turn determines cardiac filling pressures and may be modifiable through SNB.

Methods

We analyzed data from 2 prospective, single-arm clinical studies in decompensated HFrEF (splanchnic HF-1; resting hemodynamics) and ambulatory heart failure (splanchnic HF-2; exercise hemodynamics). Patients underwent invasive hemodynamics and short-term SNB with local anesthetics. SBV was simulated using heart rate, cardiac output, central venous pressure, pulmonary capillary wedge p

SUBMITTER: Fudim M 

PROVIDER: S-EPMC9990498 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature