Education mediating the associations between early life factors and frailty: a cross-sectional study of the UK Biobank.

ABSTRACT:

Objectives

Exposures in utero and during infancy may impact the development of diseases later in life. They may be linked with development of frailty, although the mechanism is unclear. This study aims to determine the associations between early life risk factors and development of frailty among middle-aged and older adults as well as potential pathways via education, for any observed association.

Design

A cross-sectional study.

Settings

This study used data from UK Biobank, a large population-based cohort.

Participants

502 489 individuals aged 37-73 years were included in the analysis.

Primary and secondary outcome measures

Early life factors in this study included being breast fed as a baby, maternal smoking, birth weight, the presence of perinatal dis

SUBMITTER: Maharani A 

PROVIDER: S-EPMC9990643 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature