Discontinuation of tofacitinib and TNF inhibitors in patients with rheumatoid arthritis: analysis of pooled data from two registries in Canada.

ABSTRACT:

Objectives

The similarity in retention of tumour necrosis factor inhibitors (TNFi) and tofacitinib (TOFA) was previously reported separately by the Ontario Best Practices Research Initiative and the Quebec cohort Rhumadata. However, because of small sample sizes in each registry, we aimed to confirm the findings by repeating the analysis of discontinuation of TNFi compared with TOFA, using pooled data from both these registries.

Design

Retrospective cohort study.

Setting

Pooled data from two rheumatoid arthritis (RA) registries in Canada.

Participants

Patients with RA starting TOFA or TNFi between June 2014 and December 2019 were included. A total of 1318 patients were included TNFi (n=825) or TOFA (n=493).

Outcome measures

Time to discontinuation was as

SUBMITTER: Movahedi M 

PROVIDER: S-EPMC9990670 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature